中华医学杂志（英文版）2003，Vol.116Issue(2)：253-257,5.
Ischemic preconditioning in immature hearts: mechanism and compatibility with cardioplegia
Ischemic preconditioning in immature hearts: mechanism and compatibility with cardioplegia
朱斌 1闵苏 2龙村 3叶铁虎1
作者信息
- 1. Department of Anesthesiology, Peking Union Medical Hospital, CAMS&PUMC, Beijing 100730, China
- 2. Department of Anesthesiology, First Hospital, Chongqing Medical University, Chon gqing 400016, China
- 3. Anesthesiology & CPB Research Group, Fuwai Hospital, CAMS & PUMC, Beijing 100730 , China
- 折叠
摘要
Abstract
Objective To investigate (1) whether ischemic preconditioning (IPC) could protect immature rabbit hearts against ischemia-reperfusion injury and (2) the role of KATP channel in the mechanism of myocardial protection. Since cardioplegia is a t raditional and effective cardioprotective measure in clinic, our study is also d esigned to probe the compatibility between IPC and cardioplegia.Results The recovery of CF, HR, LVDP and ±dp/dtmax in preconditioned hearts was b est am ong the four groups. The incidence of arrhythmia was low and less CK-MB leaked out in the IPC group. Myocardial ATP content was better preserved by IPC. Pre treatment with glibenclamide completely abolished the myocardial protection prov ided by IPC, but did not affect ischemia-reperfusion injury.Conclusions While applying cardioplegia, IPC provides significant cardioprotective effects. Activation of KATP channels is involved in the mechanism of IPC-produced cardioprotection.关键词
ischemic preconditioning/immature/KA TPchannels/ischemia/cardioplegiaKey words
ischemic preconditioning/immature/KA TPchannels/ischemia/cardioplegia分类
医药卫生引用本文复制引用
朱斌,闵苏,龙村,叶铁虎..Ischemic preconditioning in immature hearts: mechanism and compatibility with cardioplegia[J].中华医学杂志（英文版）,2003,116(2):253-257,5.
