中国药理学与毒理学杂志2004，Vol.18Issue(4)：253-258,6.
钩藤碱对脑缺血大鼠纹状体及海马单胺类递质含量的影响
Effects of rhynchophylline on monoamine transmitter contents of striatum and hippocampus in cerebral ischemic rats
摘要
Abstract
AIM To explore the protection mechanism of rhynchophylline(Rhy)on cerebral ischemic injury.METHODS The cerebral ischemic injury of rats was induced by middle cerebral artery occlusion.The extracellular fluid of striatum and hippocampus in cerebral ischemic rats was collected by using microdialytic approach at 30,60,90 and 120 min,respectively.Then norepinephrine(NE),5-hydroxyindoleacetic acid( 5-HIAA),3,4-dihydroxyphenylacetic acid(DOPAC)and homovanillic acid(HVA)were measured with reverse phase high performance liquid chromatograph-electrochemical detector.RESULTS Cerebral ischemic induced decreases in extracellular 5-HIAA,DOPAC and HVA in striatum and hippocampus,but NE was increased.Rhy inverses the changes in 5-HIAA,DOPAC,HVA and NE in cerebral ischemic rats.CONCLUSION Rhy can regulate release and metabolism of the intracerebral monoamine transmitters in striatum and hippocampus of cerebral ischemic rats.关键词
钩藤碱/脑缺血/去甲肾上腺素/羟基吲哚乙酸/3,4-二羟苯酰乙酸/高香草酸/色谱法,高效液相/微透析Key words
rhynchophylline/cerebral ischemia/norepinephrine/hydroxyindoleacetic acid/3, 4-dihydroxyphenylacetic acid/homovanillic acid/chromatography,high performance liquid/microdialysis分类
医药卫生引用本文复制引用
陆远富,谢笑龙,吴芹,文国荣,杨素芬,石京山..钩藤碱对脑缺血大鼠纹状体及海马单胺类递质含量的影响[J].中国药理学与毒理学杂志,2004,18(4):253-258,6.基金项目
贵州省省长人才基金资助课题(2001016) （2001016）
