北京大学学报（医学版）2001，Vol.33Issue(3)：255-257,3.
血卟啉衍生物脂质体瘤内注射给药在
荷瘤鼠体组织中的药物分布
Distribution of HPD in tissues and tumor in mice b y
intratumor injection of liposome-HPD
摘要
Abstract
Objective: To investigate the effect of dif ferent dosage forms of hematoporphyrin derivatives (HPD) as well as different wa ys of administration on the distribution of HPD in tumor and tissues. Me thods: Large unilamilar vesicle L-HPD was prepared using reverse phase vaporization method. The L-HPD was administered to mice with tumor by i.t. or i . p. injections.The concentrations of HPD in tumor and tissues were determined by a fluorometric method at various times after injection. Results: The average diam eter of L-HPD particles was 100-200 nm. HPD encapsulated ratio was 52.6%. Lea kage rate was within 7.6% in 72 hours. At all times after injection the concentratio n of HPD in tumor by i.t. injection of L-HPD were higher than by i.p. injection o f L-HPD, as well as by i.t. injection of free HPD, whereas the level of HPD in skin was lowest after i.t. injection of L-HPD. Concl usion: T he results suggested that, in comparison with i.p. injection of L-HPD and i.t. in jection of free HPD, the concentration of HPD in tumor was the highest after i.t . injection of L-HPD,hence the last one should be a favorable method for PDT.关键词
血卟啉衍生物/投药和剂量/血卟啉衍生物脂质体/注射,病灶内/肿瘤/药物疗法分类
医药卫生引用本文复制引用
崔国辉,沈琳,张蕾,侯新朴..血卟啉衍生物脂质体瘤内注射给药在
荷瘤鼠体组织中的药物分布[J].北京大学学报（医学版）,2001,33(3):255-257,3.
