中国病理生理杂志2001，Vol.17Issue(3)：255-258,4.
低氧大鼠冠状血管储备的变化及一氧化氮
和内皮素-1的调节作用
Changes in coronary vascular reserve and roles of nitric oxide and endothelin-1
in regulation of coronary vascular reserve during hypoxia
周玉峰 1黄梅 2谢增柱 1刘福玉 1廖为公1
作者信息
- 1. 第三军医大学病理生理教研室,
- 2. 中国人民解放军重庆通讯学院门诊部,
- 折叠
摘要
Abstract
AIM：To investigate the roles of nitric oxide (NO) and endothelin-1(ET-1) in regulation of coronary vascular reserve (CVR) during hypoxia.METHODS： CVR were measured with 99m TC radiolabelled frog RBC, the changes of NO-2，ET-1 contents， nitric oxide synthase(NOS) activity and the myocardial morphometry were observed. RESULTS： (1) Acute hypoxia caused an increase in left and right ventricular myocardial blood flow，myocardial NO-2，ET-1 contents，NOS activity，but CVR in the left and right ventricle were decreased compared with the control group.(2) Intermittent hypobaric hypoxia for 90 days did not lead to significant change in left ventricular CVR，myocardial ET-1/NO-2 ratio. However, right ventricular myocardial ET-1 contents，ET-1/ NO-2 ratio were increased，right ventricular CVR and myocardial NO-2 contents were decreased. We also observed that perivascular collagen，arterial wall thickness in right ventricle， hematocrit，RV weight index were augmented. CONCLUSION： Rest myocardial blood flow was increased，CVR was decreased；The decreased coronary vascular reserve during chronic hypoxia might be resulted from the increased hematocrit，arterial wall thickness，perivascular collagen，ET-1 content, the decreased NO content and right ventricular hypertrophy关键词
大鼠/低氧/冠状血管/一氧化氮/内皮缩血管肽类分类
医药卫生引用本文复制引用
周玉峰,黄梅,谢增柱,刘福玉,廖为公..低氧大鼠冠状血管储备的变化及一氧化氮
和内皮素-1的调节作用[J].中国病理生理杂志,2001,17(3):255-258,4.
