解放军医学杂志2001，Vol.26Issue(4)：256-258,3.
谷氨酸离子型受体拮抗剂对大鼠机械穿髓诱导的延髓Fos蛋白表达的影响
INFLUENCE OF IONOTROPIC GLUTAMATE RECEPTOR ANTAGONIST ON Fos PROTEIN EXPRESSION IN MEDULLA OBLONGATA OF THE RAT AFTER MECHANICAL DENTAL PULP EXPOSURE
徐默菡 1牛忠英 2倪龙兴 2王百忍 3饶志仁 3周训银 1贾安琦1
作者信息
- 1. 成都军区昆明总医院
- 2. 第四军医大学口腔医学院
- 3. 第四军医大学神经科学研究所
- 折叠
摘要
Abstract
To assess the roles of glutamate and its ionotropic receptor in processing noxious sensory input from dental pulp,glutamate NMDA receptor subtype antagonist,MK-801 and non-NMDA receptor subtype antagonist,CNQX were administrated separately into left lateral cerebral ventricle prior to exposing pulp cavity of left maxillary first molar tooth.The number of Fos-positive neurons in medulla oblongata was measured and compared with that of the group with simple exposure of dental after same survival time pulp.Fos protein expression was reduced dose-dependently by an administration of MK-801,but CNQX had little effect.The results showed that glutamate may be an excitatory transmitter of noxious dental pulp sensory input to neurons in medulla oblongata.In pain nodel of mechanical exposing dental pulp,NMDA receptor subtype has an important role in this process.关键词
受体,谷氨酸/牙髓/伤害性感受/基因表达分类
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徐默菡,牛忠英,倪龙兴,王百忍,饶志仁,周训银,贾安琦..谷氨酸离子型受体拮抗剂对大鼠机械穿髓诱导的延髓Fos蛋白表达的影响[J].解放军医学杂志,2001,26(4):256-258,3.
