中国临床康复2004，Vol.8Issue(13)：2592-2593,2.
海风藤选择性抑制淀粉样前体蛋白基因表达
Selective inhibition of haifengteng in gene expression of beta-amyloid precursor protein
摘要
Abstract
BACKGROUND: Beta-amyloid protein(β-AP) is a core element in senile plague and its cerebral deposition closely relates to the onset of Alzheimer' s disease(AD) . Modern researches prove that β-AP is originated form beta-amyloid precursor protein(β-APP) . If the gene expression of β-APP can be inhibited, the cerebral deposition of β-AP will decrease, and therefore, AD might be treated effectively. Hence, many national and international scholars are actively searching for the inhibitors that could inhibit the gene expression of β-APP for effective medications in AD treatment.OBJECTIVE: To study the impact of haifengteng on gene expression of β-APP in the cells of human neuroblastoma.DESIGN: Experimental control: medication intervention(haifengteng) and non-medication intervention. Gene comparison between objective gene (β-APP) and structure gene (β-Acfin).MATERIALS: Cellular serials of human neuroblastoma(SK-N-SH),haifengteng.METHODS: To observe the impact of haifengteng in different reactive strength and different reactive time on β-APP mRNA through cellular culture and RT-PCR.RESULTS: Haifengteng could selectively inhibit the gene expression of β-APP and the inhibition enhanced along with the prolongation of the reactive time and the increase of the reactive strength.CONCLUSION: The selective inhibition of haifengteng in gene expression of β-APP provides a more reliable laboratorial basis in AD prevention and treatment.关键词
阿尔茨海默病/海风藤/基因分类
医药卫生引用本文复制引用
韩恩吉,胡洪涛,何秀全,邓小梅,卢勇,周海涛..海风藤选择性抑制淀粉样前体蛋白基因表达[J].中国临床康复,2004,8(13):2592-2593,2.基金项目
国家自然科学基金(3027164) （3027164）
国家中医药管理局课题(97Z301) （97Z301）
