中德临床肿瘤学杂志（英文版）2009，Vol.8Issue(5)：260-264,5.DOI:10.1007/s10330-009-0037-3
卵巢癌术前腹腔化疗的临床应用及其评价
Clinical application of intraperitoneal chemotherapy before surgery for ovarian cancer and its evaluation
Dianyun Shi 1Mei Xiao 1Saiying Chen 1Bin Yang 1Qijiang Zhu 1Pingping Xu 1Chenfang Su1
作者信息
- 1. Department of Obstetrics and Gynecology, 81 Hospital of PLA, Nanjing 210002, China
- 折叠
摘要
Abstract
Objective:To investigate the clinical efficacy of intraperitoneal chemotherapy before surgery for ovarian cancer. Methods:60 patients with stages Ⅱ-Ⅳ of ovarian cancer were treated with intraperitoneal chemotherapy of CAP or TP regimen followed by a surgery treatment and another chemotherapy for 6 cycles. And then the efficiency of the therapy was evaluated by analyzing the changes of ascites, the serum CA-125 and CA-19-9 levels and the findings in the operation, and investigating the recurrence of cancer and the survival. Results:After 1-3 cycles of intraperitoneal chemotherapy, serum levels of CA-125 and CA-19-9 and carcinous ascites significantly reduced in all patients, ascites reduce was over 50% in 98.3% cases;all cases were successfully treated with cytoreduction and it was found during the operation that bulky tumor was reduced and looser so as to be easily isolated and removed;PFS of the patients was prolonged, while the toxicity and side-effects were not so serious as beyond the patient toleration. Conclusion:Intraperitoneal chemotherapy before surgery for ovarian cancer has an active efficacy in clinic, being able to improve conditions of surgery and increase the opportunity of maximal cytoreduction, and prolong survival of the patients, and should be a good selection for the treatment of advanced ovarian cancer.关键词
ovarian cancer/intraperitoneal chemotherapy/clinical application/evaluationKey words
ovarian cancer/intraperitoneal chemotherapy/clinical application/evaluation分类
医药卫生引用本文复制引用
Dianyun Shi,Mei Xiao,Saiying Chen,Bin Yang,Qijiang Zhu,Pingping Xu,Chenfang Su..卵巢癌术前腹腔化疗的临床应用及其评价[J].中德临床肿瘤学杂志（英文版）,2009,8(5):260-264,5.
