中国临床药学杂志2008，Vol.17Issue(5)：262-264,3.
布地奈德雾化对慢性阻塞性肺疾病合并糖尿病患者的疗效及糖代谢的影响
Efficacy of inhaled budesonide on chronic obstructive pulmonary disease concurrent with diabetes and glycometabolism in patients
李向阳 1顾芹 2盛华 1沈维敏1
作者信息
- 1. 复旦大学附属华东医院,呼吸科,上海,200040
- 2. 复旦大学附属华东医院,内分泌科,上海,200040
- 折叠
摘要
Abstract
AIM To evaluate the clinical efficacy of inhaled budesonide on chronic obstructive pulmonary disease (COPD)patients with diabetes.METHODS Sixty patients with stable COPD and diabetes were randomly divided into two groups:budesonide group and control group.Both groups were received ipmtropium bromide 500μg twice a day by the inhalation of oxygen-driven.Budesonide group was also inhaled budesonide 2 mg twice a day.Forced expiratory volume in one second(FEV1),FEV1pred(FEV1%),arterial partial pressure of oxygen(PaO2),fasting plasma glucose (FPG)and glycated haemoglobin(HbA1c)were measured before and after treatment for 3,6 months.RESULTS After 3 nmnths,FEV1 of patients in budesonide group was improved from(1.27±0.20)L to(1.49±0.21)L(P＜0.01) and FEV1% was improved from(64.14±6.37)to(74.76±7.62)(P＜0.01)which was significant higher than that in control group(P＜0.05).The PaO2,FPG,HbA1c of all the matients were not significant during the test(P＞0.05).CONCLUSION The study suggests that the treatment with inhaled budesonide could improve pulmonary ventilation function without affecting the shcose metabolism.关键词
布地奈德/慢性阻塞性肺疾病/肺功能/糖代谢Key words
budesonide/chronic obstructive pulmonary disease/pulmonary function/glycometabolism分类
医药卫生引用本文复制引用
李向阳,顾芹,盛华,沈维敏..布地奈德雾化对慢性阻塞性肺疾病合并糖尿病患者的疗效及糖代谢的影响[J].中国临床药学杂志,2008,17(5):262-264,3.
