广东医学2001，Vol.22Issue(1)：26-27,2.
谷氨酰胺防治梗阻性黄疸肠道细菌移位
Prevention of bacterial translocation by glutamine in trats with obstructive jaundice
摘要
Abstract
Objective To study the influence of glutamine on bacterial translocation of rats with obstructive jaundice (OJ). Methods 90 rats were divided randomly into three groups (control, OJ and Glutamine group)(n=30), OJ model was induced by obstruction of common bile duct. Rats in glutamine group were fed with glutamine once daily. The histology and DNA content of intestine mucosa and the number of E.Coli labeled with acridine orange in mesentery lymph node (MLN) were observered. Results There were obvious lesions in the intestinal mucosa and significant decrease in DNA content in mucosa (P＜0.01). The number of E. Coli labeled with acridine orange in MLN increased significantly (P＜0.01) in OJ group. Mucosa injury and the number of bacteria were reduced by glutamine. Conclusion Glutamine may help to maintain the mucosal barrier function and reduces bacterial translocation in OJ.关键词
阻塞性黄疸/谷氨酰胺/细菌移位分类
医药卫生引用本文复制引用
龚时文,赵志毅,黄春南,张明,黄擎雄..谷氨酰胺防治梗阻性黄疸肠道细菌移位[J].广东医学,2001,22(1):26-27,2.基金项目
本研究为广东省医学科研基金资助课题 （）
