南京医科大学学报（英文版）2006，Vol.20Issue(1)：26-29,4.
Adipose tissue resistin gene expression in DIO and DR rats
Adipose tissue resistin gene expression in DIO and DR rats
摘要
Abstract
Objective: To investigate the expression of resistin gene in diet-induced obesity (DIO) and diet resistance (DR)rats. Methods: DIO and DR models were prepared with male SD rats after 6 weeks feeding by a diet of relatively high fat, sucrose, and caloric content (HE diet). Body-weight, fat mass, and the concentration of serum insulin were measured, and the expression of resistin and Peroxisome proliferator-activated receptory-γ(PPAR-γ) gene in whit adipose tissue (WAT) was also detected by RT-PCR. Results: ①Body weight, fat mass and the concentration of serum insulin were significantly increased in DIO rats and decreased in DR rats. ② The expression of resistin and PPARγ gene was upregulated in DIO group and supressed in DR group, but the expression of resistin was not detectable in all samples within three groups. Conclusion: Resistin may serve as a link between obesity and insulin resistance, but the individual difference is enormous.关键词
obesity/DIO/DR/resistin/insulin resistanceKey words
obesity/DIO/DR/resistin/insulin resistance分类
医药卫生引用本文复制引用
Yuanyuan Zhao,Yuhui Ni,Xirong Guo,Haixia Gong,Xia Chi,Ronghua Chen..Adipose tissue resistin gene expression in DIO and DR rats[J].南京医科大学学报（英文版）,2006,20(1):26-29,4.基金项目
Natural Science Foundation (Grant Number: 30371502), Natural Science Foundation of Jiangsu Province (Grant Number: BK2001120) （Grant Number: 30371502）
