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多通道神经信号激励模块的研制及其动物实验

李文渊 王志功 吕晓迎 顾晓松 张震宇

东南大学学报(英文版)2007,Vol.23Issue(1):26-30,5.
东南大学学报(英文版)2007,Vol.23Issue(1):26-30,5.

多通道神经信号激励模块的研制及其动物实验

Multi-channel neural signal stimulating module and in-vivo experiments

李文渊 1王志功 1吕晓迎 2顾晓松 3张震宇1

作者信息

  • 1. 东南大学射频与光电集成电路研究所,南京,210096
  • 2. 东南大学生物电子学国家重点实验室,南京,210096
  • 3. 南通大学江苏省神经再生重点实验室,南通,226001
  • 折叠

摘要

Abstract

The module for function electrical stimulation (FES) of neurons is designed for the research of the neural function regeneration microelectronic system, which is an in-body embedded micro module. It is implemented by using discrete devices at first and characterized in vitro. The module is used to stimulate sciatic nerve and spinal cord of rats and rabbits for in-vivo real-time experiments of the neural function regeneration system. Based on the module, a four channel module for the FES of neurons is designed for 12 sites cuff electrode or 10 sites shaft electrode. Three animal experiments with total five rats and two rabbits were made. In the in-vivo experiment, the neural signals including spontaneous and imitated were regenerated by the module. The stimulating signal was used to drive sciatic nerve and spinal cord of rats and rabbits, successfully caused them twitch in different parts of their bodies, such as legs, tails, and fingers. This testifies that the neural function regeneration system can regenerate the neural signals.

关键词

微电极/神经功能再生/神经功能激励/神经信号通道/激励

Key words

microelectrode/neural function regeneration/function electrical stimulation/neural signal channel/stimulation

分类

医药卫生

引用本文复制引用

李文渊,王志功,吕晓迎,顾晓松,张震宇..多通道神经信号激励模块的研制及其动物实验[J].东南大学学报(英文版),2007,23(1):26-30,5.

基金项目

The National Natural Science Foundation of China (No.69825101,90377013). (No.69825101,90377013)

东南大学学报(英文版)

1003-7985

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