解放军医学杂志2001，Vol.26Issue(4)：264-266,3.
幼鼠实验性肺炎右室心肌细胞L型钙电流的记录
AN EXPERIMENTAL STUDY ON L-TYPE CALCIUM CURRENT OF RIGHT VENTRICULAR MYOCYTES IN JUVENILE RAT MODELS OF ACUTE PNEUMONIA
刘道明 1陈新民 1肖家思 2任榕娜 1叶礼燕 1洪新如1
作者信息
- 1. 南京军区福州总医院
- 2. 第三军医大学生理教研室
- 折叠
摘要
Abstract
To probe the myocardial calcium metabolism during heart failure subsequent to acute pneumonia, the L-type Ca2+ current through the right ventricular myocyte membrane of juvenile rat pneumonia models was recored. 50-day old Wister rats were given via trachea staphylococci aureus or sterile normal saline as control. Right ventricular myocytes were enzymatically isolated and L-type Ca2+ currents were recorded with the whole-cell clamp technique. The results showed that the currents were not significantly changed 24 hours after staphylococci aureus administration but were significantly augmented 120 hours after staphylococci aureus administration.No change was found in peak potential and activation potential. It is concluded that L-type Ca2+ currents of right ventricular myocytes don′t change during early stage of acute pneumonia but are augmented during later period. And pneumonia has little effect on peak potential and activation potential.关键词
肺炎/心室功能障碍,右/膜片钳术/钙通道,L型分类
医药卫生引用本文复制引用
刘道明,陈新民,肖家思,任榕娜,叶礼燕,洪新如..幼鼠实验性肺炎右室心肌细胞L型钙电流的记录[J].解放军医学杂志,2001,26(4):264-266,3.
