中德临床肿瘤学杂志（英文版）2009，Vol.8Issue(5)：269-272,4.DOI:10.1007/s10330-009-0054-2
VEGF基因多态性与肺痛遗传危险因素的关系
Vascular endothelial growth factor polymorphisms and risk of lung cancer
摘要
Abstract
Objective:We investigated the potential association between vascular endothelial growth factor (VEGF) poly-morphisms and the risk of lung cancer. Methods:In the case-control study, we used PCR-RFLP technique to determine two VEGF genotypes-2578C/A and 936C/T in 171 lung cancer patients and 172 healthy controls for conformation, and construct-ed haplotypes of the two gene sites by PHASE1.0 software. Unconditional logistic regression model was used to analyze the statistical association of genontypes or haplotypes in the two groups adjusted by gender and age. Results:Compared with at least one -2578A allele, individuals with-2578CC genotype found associated with a significantly decreased risk of lung can-cer [P=0.001;adjusted odds ratio (OR), 0.391;95% confidence interval (95% CI), 0.226-0.686]. Analyses stratified by gender showed that the combined -2578 CA and AA genotype were also associated with a significantly decreased risk of lung cancer. (P=0.016;OR 0.303;95% CI=0.153-0.601 and P=0.018;OR=0.547;95% CI=0.331-0.903, respectively). The distribu-tion of the two haplotypes (936C/-2578C and 936C/-2578A) were significantly different between case-and -control groups (P = 0.016, OR=0.317, 95% CI=0.124-0.809 and P=0.018, OR=0.547, 95% CI=0.331-0.903). Analyses categorized by tumor histology showed that Haplotype C-C was associated with a significantly decreased risk of adenocarcinoma compared with the reference haplotypes. (P=0.004;OR=0.237;95% CI=0.090-0.627). Conclusion:These results suggest that the VEGF polymorphisms may be a critical factor for the risk of lung cancer.关键词
lung neoplasms/vascular endothelial growth factor/risk factor/genetic polymorphismKey words
lung neoplasms/vascular endothelial growth factor/risk factor/genetic polymorphism分类
医药卫生引用本文复制引用
Jing Liang,Xinshuang Yu,Xiaolin Liu,Dianshui Sun,Hairong Liu,Wei Hu,Aizhong Qu,Yan Li..VEGF基因多态性与肺痛遗传危险因素的关系[J].中德临床肿瘤学杂志（英文版）,2009,8(5):269-272,4.基金项目
Supported by a grant from the Shandong Provincal Natural Sciences Foundation (No. 2005ZX04). （No. 2005ZX04）
