癌症2001，Vol.20Issue(3)：270-273,4.
涎腺恶性淋巴上皮病变临床病理特征及其与EB病毒的相关性
Clinical Pathological Characteristics of Malignant Lymphoepithelial Lesion of the Salivary Glands and Its Relationship with EB Virus
饶慧兰 1侯景辉 1黄奕莉 1郝亚萍 1张惠忠 1邵建永 1林汉良2
作者信息
- 1. 中山医科大学肿瘤防治中心病理科,
- 2. 中山医科大学病理教研室,
- 折叠
摘要
Abstract
Objectives：This study was designed to investigate the clinical pathological characteristics of malignant lymphoepithelial lesion(MLEL) of salivary glands and the relationship with EBV（ Epstein-Barr Virus） . Methods：In situ hybridization and immunohistochemical methods were used to detect EBERs (EBV-encoded small RNAs), latent membrane protein 1 (LMP1), EBNA2(EB nuclear antigen-2), and ZEBRA (Z EBV replication activator) in paraffin embedded tissues of 41 MLEL cases. Results：(1)Forty cases of MLEL showed staining with EBERs. Positive rate of EBERs by in situ hybridization in 41 cases of MLEL was 97.56％ . (2)LMP1 expression was detected in 75.6％ (31/41), positive rate of ZEBRA was 2.5％ (1/41), no EBNA2 was found (0/20). Conclusion：EBV might play an important role in pathogenesis of MLEL.关键词
涎腺恶性淋巴上皮病变/Epstein-Barr病毒/原位杂交/免疫组化分类
医药卫生引用本文复制引用
饶慧兰,侯景辉,黄奕莉,郝亚萍,张惠忠,邵建永,林汉良..涎腺恶性淋巴上皮病变临床病理特征及其与EB病毒的相关性[J].癌症,2001,20(3):270-273,4.
