安徽医科大学学报2001，Vol.36Issue(1)：27-28,2.
nm23基因产物与肺癌转移及预后关系研究
Relationship between product of nm23 gene
and metastasis prognosis of lung cancer
马冬春 1疏元善 1魏大中 1范军 1魏鲲鹏2
作者信息
- 1. 安徽省立医院胸外科
- 2. 安徽省六安市人民医院外科
- 折叠
摘要
Abstract
Objective To explore the relationship between the expression of nm23 gene and metastasis, prognosis of lung cancer. Methods 82 lung cancers were examined with S-P immunohistochemical staining for the expresssion of nm23 gene,they were divided into groups, contrasted and analysed according to their metastasis and prognosis. Results 60 lung cancers were positive expression of nm23 gene,the positive rate of nm23 gene was 20.0% in lung cancers with metastasis, 96.5% with non-metatasis, the difference was significant(P<0.01). The positive rate of nm23 gene was higher(90.6%) in the lung cancers with whose postoperative survival time extended 3-year than that (57.8%) of less than 3-year, there were statistical significances between the expression of nm23 gene and the prognosis of lung cancers(P<0.01). Conclusion The down-regulation expression of nm23 gene was involved not only in the metastasis of lung cancers, but also in the bad prognosis of lung cancers. The expression of nm23 gene may be regarded as an important reference index in judging the metatasis and prognosis of lung cancers.关键词
肺肿瘤/免疫组织化学/肿瘤转移分类
医药卫生引用本文复制引用
马冬春,疏元善,魏大中,范军,魏鲲鹏..nm23基因产物与肺癌转移及预后关系研究[J].安徽医科大学学报,2001,36(1):27-28,2.
