河北北方学院学报（医学版）2008，Vol.25Issue(1)：27-31,5.
MGMT和Survivin在乳腺癌中的表达及其临床意义
Expression of MGMT and Survivin in Breast Cancer and Its Clinical Significance
王发亮 1薄爱华 2芦广萍 2侯金超 1吴荣薇1
作者信息
- 1. 河北北方学院大学生科协,河北,张家口,075000
- 2. 河北北方学院电镜室,河北,张家口,075000
- 折叠
摘要
Abstract
Objective:To investigate the expression of MGMT and Survivin in breast cancer and its clinical significance.Methods:Specimens from breast adenoma and breast cancer were taken and had been Formalin-fixed,paraffin-embedded.With Strept Avidin-Biotin Complex(SABC) immunohistochemical technique,the expression of MGMT and Survivin in these specimens was examined.Results:It was found that there were significant differences between MGMT and Survivin in breast adenoma and breast lymph node metastasis,while the expression of Survivin was associated with lymph node metastasis only.Meanwhile,the expression of MGMT was correlated with that of Survivin(r=0.34,P<0.01).Conclusion:It was concluded that the abnormal expressions of MGMT and Survivin were associated with lymph node metastasis.They possibly could be useful indexes for the primary screening and the prognosis of breast cancer.The examination of them may have an important guiding significance in the chemotherapy strategy.关键词
O6-甲基鸟嘌呤-DNA-甲基转移酶/生存素/乳腺肿癌Key words
O6-methyguanine-DNA methytransferase(MGMT)/Survivin/Breast neoplasms分类
医药卫生引用本文复制引用
王发亮,薄爱华,芦广萍,侯金超,吴荣薇..MGMT和Survivin在乳腺癌中的表达及其临床意义[J].河北北方学院学报（医学版）,2008,25(1):27-31,5.
