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人参皂甙与IL-2协同诱导PBMC对恶性脑胶质瘤细胞杀伤活性研究

罗俊生 顾立学 席焕久 魏炳杰 刘兴波 邱建武 张鹏飞 单宏仁

中国肿瘤生物治疗杂志2000,Vol.7Issue(4):273-274,2.
中国肿瘤生物治疗杂志2000,Vol.7Issue(4):273-274,2.

人参皂甙与IL-2协同诱导PBMC对恶性脑胶质瘤细胞杀伤活性研究

Cytotoxicity of GS and IL-2 Activated PBMC to Malignant Glioma Cells

罗俊生 1顾立学 1席焕久 1魏炳杰 1刘兴波 1邱建武 1张鹏飞 1单宏仁1

作者信息

  • 1. 锦州医学院附属一院神经外科 锦州 121001
  • 折叠

摘要

Abstract

Objective: To investigate a new method for improving the therapeutic effect on malignant glioma. Methods: A new type of killer cells, named GS-LAK, was induced by means of costimulating the peripheral ginsenoside(GS) and interleukin-2 (IL-2). Comparing with control group-LAK cells, cytotoxicity of GS-LAK cells against malignant glioma cells(BT325) was examined with MTI method. Results: It showed that GS-LAK cells exhibited some advantages over LAKcells in proliferation, cytotoxicity, as well as the utilizing of IL-2. Conclusion: The application of GS-LAK cells mightopen a new prospect to clinical therapeutic approach to malignant glioma.

关键词

人参皂甙/IL-2/BT325/杀伤活性

Key words

ginsenoside/IL-2/BT325/eytotoxicity

分类

医药卫生

引用本文复制引用

罗俊生,顾立学,席焕久,魏炳杰,刘兴波,邱建武,张鹏飞,单宏仁..人参皂甙与IL-2协同诱导PBMC对恶性脑胶质瘤细胞杀伤活性研究[J].中国肿瘤生物治疗杂志,2000,7(4):273-274,2.

基金项目

本文为中国免疫学会推荐稿,受辽宁省教委科研基金(991721599)资助 (991721599)

中国肿瘤生物治疗杂志

OACSTPCD

1007-385X

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