中国中西医结合杂志2001，Vol.21Issue(4)：274-276,3.
黄芪注射液对早期糖尿病肾病患者血小板
功能和血浆内皮素的影响
Effect of Astragalus Injection on Platelet Function and Plasma Endothelin in Patients with Early Stage Diabetic Nephropathy
刘志强 1李全志 2秦贵军3
作者信息
- 1. 河南省开封医学专科学校附属淮河医院,
- 2. 河南省开封市肿瘤医院
- 3. 河南医科大学第一附属医院
- 折叠
摘要
Abstract
To study the therapeutic effect of Astragalus injection (AI) in treating early stage diabetic nephropathy (DN) patients. Methods: The total of 136 early diabetic nephropathy patients were randomly divided into two groups, 50 cases in the conventional treated group and 86 in the AI treated group, the therapeutic course being 3 weeks. Levels of plasma endothelin-1 (ET-1), 24 hrs urinary albumin excretion rate (uAER), and platelet granule membrane protein (GMP-140), 6-keto-prostaglandin F1α (6-keto-PGF1α), and thromboxane B2 (TXB2) before and after treatment were determined by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) respectively. Moreover, the above-mentioned criteria in 26 healthy subjects were also measured for control. Results: The plasma ET-1, GMP-140, TXB2 and uAER levels in DN patients were higher, but 6-keto-PGF1α level was lower than those in healthy subjects. The above elevated criteria in DN patients could be lowered by AI treatment. Conclusion: The pathogenesis and development of DN might be closely associated with the changes of plasma ET-1 level and platelet function. Astragalus could improve the above-mentioned changes in patients of early stage DN.关键词
糖尿病肾病/内皮素/血小板功能分类
医药卫生引用本文复制引用
刘志强,李全志,秦贵军..黄芪注射液对早期糖尿病肾病患者血小板
功能和血浆内皮素的影响[J].中国中西医结合杂志,2001,21(4):274-276,3.
