中国组织工程研究与临床康复2008，Vol.12Issue(14)：2757-2760,4.
聚乳酸膜等离子接枝聚合聚乙烯基吡咯烷酮及表面性能研究
Surface modification of poly-D,L-lactic acid film with plasma graft polymerization
摘要
Abstract
BACKGROUND:Polylactic acid(PLA)surface is hydrophobic and there are no nataral recognition sites,so its application is limited.Many different strategies have been studied such as composition and chemical Drafting,to produce hydrophilic groups.However,these traditional methods are always involved in complex process and many organic reagents,resulting in decrease of biocompatibility.OBJECTIVE:To conduct the surfacr modification of PL.A and improve its hydrophilicity with low temperature plasma treatment.DESIGN:Controlled observation.SETTING:Department of Materials Science and Engineering in Jinan University.MATERIAIS:The experiment was processed from October 2004 to October 2005 at Guangzhou Research Center of Artificial Organs and Materials Engineering(Ministry of Education).The mainly used materials were:Poly-D,L-lactic acid(Mr 2.9×104,Shandong Medical Instrument Institute),N-vinyl-pyrrolidone(NVP,Acros Company,purified before use).METHODS:The materials were treated in the plasma reactor under different conditions(power=150 W,t=3,2,1 minutes;power=30 W,t=10,8,5,3,1 minutes)to choose the optimal condition,and then PLA were grafted with NVP by gas phase polymerization and liquid polymerization,respectively.MAIN OUTCOME MEASURES:THe surface morphology of the films was observed with scanning electron microscopy and atomic force microscopy.The hydrophilicity of native and treated material surfaces was measured using a water contact angle meter.Surface composition was detected with Fourier transform infrared spectrometer.Mass changesmeasurement was applied to characterize the grafting efficiency.RESULTS:Scanning electron microscopy and atomic force microscopy showed that the plasma medified materials possessed coarse surface with pores and notches.Water contact angles decreased obviously from 78°to 50°after grafting,Fourier transform infrared spectrometer showed a new absorption peak at 1 637.19 cm-1,which corresponded to the carbonyl stretch vibration absorption of amide group in poly-N-vinyl-pyrrolidone.After the plasma treatmerlt at low temperature.the mass change ratio of PLA film material was-0.6.CONCLUSION:The plasma treatment and polymerization can improve the hydrophilicity and cause coarsr surface of PLA material,which will be helpful for the cell attachment.关键词
聚乳酸/乙烯基吡咯烷酮/等离子/接枝聚合分类
医药卫生引用本文复制引用
李立华,丁珊,田冶,田金环,周长忍..聚乳酸膜等离子接枝聚合聚乙烯基吡咯烷酮及表面性能研究[J].中国组织工程研究与临床康复,2008,12(14):2757-2760,4.基金项目
国家自然科学基金资助(30170272) （30170272）
广东省重大专项基金资助(A302020104).Supported by:the National Natural Science Foundation of China,No.30170272 （A302020104）
Major Program of Guangdong Science and Technology,No.A302020104 （）
