中德临床肿瘤学杂志（英文版）2005，Vol.4Issue(5)：276-278,3.
谷胱甘肽硫转移酶M1与Tl基因缺失增加鼻咽癌易感性
Glutathione S-transferase M1 and T1 Gene Deletion Associated with Increased Susceptibility to Nasopharyngeal Carcinoma
摘要
Abstract
Objective: To evaluate the association of Glutathione S-transferase (GST) M1 and T1 genetic polymorphisms and susceptibility to nasopharyngeal carcinoma (NPC) in a high risk area of Guangxi Zhuang Autonomous Region (province), Southwest of China. Methods: A case-control study was conducted to investigate the genetic polymorphisms of these enzymes (GSTM1 and GSTT1 null genotypes).A total of 127 NPC cases and 207 controls were recruited. Results: GSTM1 and GSTT1 null genotype frequencies were higher among NPC patients at a level of statistical significance (P＜0.005; P＜0.001respectively), and both GSTM1 and GSTT1 null genotype were even more significant (P＜0.001). Conclusion: NPC is the most common cancer in Guangxi. GST enzymes are involved in the detoxification of many environmental carcinogens. Homozygous deletions of GSTM1 and GSTT1 have been associated with several types of cancer. The risk to develop NPC has been associated with environmental factors such as cigarette smoking and EB virus infection. The present results indicate that the GSTM1 and GSTT1deletion polymorphisms are associated with an increase risk of susceptibility to NPC, and both detoxific enzyme genes deletion is more important than a single gene deletion for the susceptibility to NPC.关键词
癌症/鼻咽/谷胱甘肽硫转移酶M1,T1Key words
carcinoma/nasopharyngeal/glutathione S-transferase M1/glutathione S-transferase T1分类
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邓卓霖,韦义萍..谷胱甘肽硫转移酶M1与Tl基因缺失增加鼻咽癌易感性[J].中德临床肿瘤学杂志（英文版）,2005,4(5):276-278,3.
