中国动脉硬化杂志2009，Vol.17Issue(4)：281-284,4.
大鼠缺血性心肌损伤后早期抑制核因子κB对心肌修复的影响
Effects of Inhibition of Nuclear Factor-κB in the Early Phase After Myocardial Ische-mia on Myocardial Reparation in Rats
潘波 1杨成明 1曾春雨 1熊秀勤 2王旭开 1王红勇1
作者信息
- 1. 第三军医大学大坪医院野战外科研究所心血管内科,重庆市,400042
- 2. 第三军医大学大坪医院野战外科研究所超声诊断科,重庆市,400042
- 折叠
摘要
Abstract
Aim To study the effects of inhibition of NF-κB in the early phase after myocardial ischemia on myo-cardial reparation in rats. Methods The myocardial ischemic injury models were established by hypodermic injection of high dose of ISO in rats. Surviving rats were randomly divided into experimental group and treated group, meanwhile control group was set.Then treated group was injected PDTC 100 mg/(kg·d) for 26 days. Myocardial pathomorphologic changes, NF-κBp65 activation, capillary density and myofibroblast accumulation were investigated. Then cardiac structure and function were assessed by echocardiography on day 14 and 28 of experiment. Results Cardiac necrotic areas were similar between experimental group and treated group. PDTC inhibited the activation of myocardial NF-κB,delayed the replacement of the damaged myocardium with granulation tissue, significantly depressed capillary density in the border area of necrosis and decreased myofibroblast accumulation in the zone of necrosis. The ratio of ventricular aneurysm formation in treated group was higher than experimental group. On day 28, the left ventricular functions in treated group were worse than that in experimental group. Conclusion Inhibition of NF-κB in the early phase after experimental myocardial ischemic injury in rats may be adverse to myocardial reparation, and may aggravate heart failure.关键词
吡咯烷二硫代氨基甲酸盐/核因子κB/异丙肾上腺素/大鼠/心肌缺血性损伤/心肌修复Key words
Pyrrolidine Dithiocarbamate/ Nuclear Factor-κB/ Isoprenaline/ Rats/ Myocardial Ischemic In-jury/ Myocardial Reparation分类
医药卫生引用本文复制引用
潘波,杨成明,曾春雨,熊秀勤,王旭开,王红勇..大鼠缺血性心肌损伤后早期抑制核因子κB对心肌修复的影响[J].中国动脉硬化杂志,2009,17(4):281-284,4.
