中德临床肿瘤学杂志（英文版）2006，Vol.5Issue(4)：282-284,3.
Gemcitabine Modulates the Microvessel Density and Apoptosis in Radiotherapy of Cervical Cancer
Gemcitabine Modulates the Microvessel Density and Apoptosis in Radiotherapy of Cervical Cancer
HU Jianli 1YU Shiying 2XIONG Huihua 2YUAN Xianglin2
作者信息
- 1. Center of Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China
- 2. Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China
- 折叠
摘要
Abstract
Objective: To evaluate the effects of gemcitabine on the microvessel density MVD) and apoptosis in radiotherapy of cervical cancer. Methods: Forty-seven patients with locally advanced cervical cancer(ⅡB, Ⅲ and ⅣA stage) were divided into two groups randomly: group A, 22 cases receiving radiotherapy combined with gemcitabine; group B, 25 cases receiving radiotherapy only. Tissue specimens were obtained from cervical tumor of all patients before and 24 h after radiotherapy with 10 Gy. MVD and apoptosis was detected by immunohistochemical staining and TUNEL assay respectively, Results: MVD (median)in group A was significantly reduced as compared with group B (P=0.001). A-LI (median) in group A was significantly increased as compared with group B (P=0.034). T0.5 in group A was significantly shorter than that in group B (P=0.018). The reduction of MVD in group A was negatively correlated with T0.5(r=-0.628). There was no significant difference in gastrointestinal and haematological adverse effects between group A and group B. Conclusion: Gemcitabine, a novel potential radiosensitizer, can decrease the neoangiogenesis, increase the apoptosis in the early stage of radiotherapy of cervical cancer.关键词
cervical cancer/radiotherapy/gemcitabine/microvessel density/apoptosisKey words
cervical cancer/radiotherapy/gemcitabine/microvessel density/apoptosis分类
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HU Jianli,YU Shiying,XIONG Huihua,YUAN Xianglin..Gemcitabine Modulates the Microvessel Density and Apoptosis in Radiotherapy of Cervical Cancer[J].中德临床肿瘤学杂志（英文版）,2006,5(4):282-284,3.
