同济大学学报（医学版）2001，Vol.22Issue(1)：28-30,33,4.
人参总皂甙对大鼠肾缺血再灌注损伤的保护作用
Protective Effects of Ginsenosides against Acute Renal Injury
Due to Ischemia-Reperfusion in Rats
姚红 1朱玲 1孙向华2
作者信息
- 1. 同济大学医学院病理生理教研室,
- 2. 同济大学附属同济医院肾脏病实验室,
- 折叠
摘要
Abstract
Objective To investigate the protective effects of ginsenosides(GS) on renal ischemia-reperfusion injuryin rats. Methods Rat renal ischemia models with right nephrectomy and occlusion of the left renal pedicle for 60 min. were used in this experiment. The changes of serum and renal malondialdehyde(MDA), the activity of superoxide dismutase (SOD), and renal morphology after GS administration were studied at 30 and 120 min. reperfusion after 60 min renal ischemia to observe its protective effects. Results With renal ischemia and reperfusion, SOD activities declined and MDA content significantly increased, and these effects could be partially depressed (P<0.01) when GS was infused. GS could also relieve the renal tissue injury. Conclusion GS might serve as an oxygen free radicals(OFR) scavenger preventing or antagonizing the toxic effects of OFR generated from renal ischemia reperfusion.关键词
肾/人参/皂甙类/过氧化脂质类/超氧化物歧化酶/缺血/再灌注/大鼠分类
医药卫生引用本文复制引用
姚红,朱玲,孙向华..人参总皂甙对大鼠肾缺血再灌注损伤的保护作用[J].同济大学学报（医学版）,2001,22(1):28-30,33,4.
