中国现代医学杂志2004，Vol.14Issue(23)：28-30,34,4.
N-Cadherin,E-Cadherin在直肠癌中的表达及临床意义
Clinical significance of N-Cadherin,E-Cadherin expression in rectal carcinoma
佟金学 1刘明 1王智勇 2徐文怀2
作者信息
- 1. 哈尔滨医学大学附属肿瘤医院,腹部外科,黑龙江,哈尔滨,150040
- 2. 北京大学第一医院,外科,北京,100034
- 折叠
摘要
Abstract
Objective: To discuss expression of E-cadherin, N-cadherin in rectal cancer and their relationship with clinical and pathological factors. Methods: Expression of N-cadherin and E-cadherin in 86 rectal cancer samples and normal rectal tissues was studied by immunohistochemical stain. Results: Both E-cadherin and N-cadherin expression were positive in 39 (45%) patients and negative in 47 (55%) patients. The positive rate of N-cadherin or negative rate of E-cadherin was positively related to the malignant degree, stage, invasion, metastasis and prognosis of the cancer .There was prominent significance (P ＜0.01) between the two groups; N-cadherin was not expressed in normal 86 rectal tissues, while E-cadherin was highly expressed. Conclusion: The abnormal expression of N-cadherin and low-level or non-expression of E-cadherin is an important factor for the invasion and metastasis of rectal cancer, it influences the 5-year survival rate. N and E -cadherin may act as indicators to the malignant degree and the prognosis of the rectal cancer.关键词
直肠癌/N-钙粘附素/E-钙粘附素Key words
rectal cancer/, N-cadherin/E-cadherin分类
医药卫生引用本文复制引用
佟金学,刘明,王智勇,徐文怀..N-Cadherin,E-Cadherin在直肠癌中的表达及临床意义[J].中国现代医学杂志,2004,14(23):28-30,34,4.
