中德临床肿瘤学杂志（英文版）2005，Vol.4Issue(5)：284-286,3.
乏氧诱导因子-1α在非小细胞肺癌中的表达研究
Expression of Hypoxia Inducible Factor 1α and Its Significance in Non-small Cell Lung Cancer
夏曙 1于世英 1袁响林1
作者信息
- 1. 武汉华中科技大学同济医学院附属同济医院肿瘤科 430030
- 折叠
摘要
Abstract
Objective: To explore the expression level and its clinical significance of hypoxia inducible factor 1α (HIF-1α) in non-small lung cancer. Methods: The expression of HIF-1α was detected in 68 human non-small lung cancer samples by immunohistochemistry. Results: (1) Thirty-nine (57.35%) out of the 68human non-small lung cancer samples was positive for HIF-1α; (2) The positive rate of HIF-1α in adenocarcinoma and squamous carcinoma was 54.76% (23/42) and 61.54% (16/26) respectively. No significant difference was found between adenocarcinoma and squamous carcinoma of non-small lung cancer in the expression of HIF-1α (P＞0.05). The positive rate of HIF-1α in middle-high differentiation was 74.28%(26/35), significantly higher than in low differentiation (39.39%, 13/33) (P＜0.05); (3) The positive expression of HIF-1α was not correlated to the sexes, ages, tumor stage and lymph node status. Conclusion:The expression of HIF-1α is higher in non-small lung cancer and is correlated to differentiation.关键词
非小细胞肺癌/乏氧诱导因子-1αKey words
non-small lung cancer/hypoxia-inducible factor 1α分类
医药卫生引用本文复制引用
夏曙,于世英,袁响林..乏氧诱导因子-1α在非小细胞肺癌中的表达研究[J].中德临床肿瘤学杂志（英文版）,2005,4(5):284-286,3.
