中德临床肿瘤学杂志（英文版）2009，Vol.8Issue(5)：286-288,3.DOI:10.1007/s10330-009-0039-1
eIF-4E、p53在皮肤鳞状细胞癌中的表达及其临床意义
The expression and the clinical significance of eukaryotic translation initiation factors 4E and p53 in squamous cell carcinoma
Shenqiu Li 1Qinjing Wei1
作者信息
- 1. Department of Dermatology, TongJi Hospital, TongJi Medical College, Huazhong University of Science and Technology, Wuhan 430030
- 折叠
摘要
Abstract
Objective:To study the expression of eukaryotic initiation factor-4E (eIF-4E) and p53 in squamous cell carcino-mas (SCC) and to explore their relationship and clinical significance. Methods:The expression of eIF-4E and p53 in 32 cases of SCC was detected by immunohistochemical SABC method. Results:The positive rate of eIF-4E and p53 expression was 93.8% and 56.3% in SCC, and the levels of eIF-4E and p53 were significantly higher in SCC than those in the normal skin tissue (P < 0.05). Conclusion:Both eIF-4E and p53 were useful markers in SCC, but the specialty and sensitivity of the eIF-4E protein was high in SCC.关键词
squamous cell carcinoma (SCC)/eukaryotic initiation factor-4E (eIF-4E)/p53Key words
squamous cell carcinoma (SCC)/eukaryotic initiation factor-4E (eIF-4E)/p53分类
临床医学引用本文复制引用
Shenqiu Li,Qinjing Wei..eIF-4E、p53在皮肤鳞状细胞癌中的表达及其临床意义[J].中德临床肿瘤学杂志（英文版）,2009,8(5):286-288,3.
