中国现代医学杂志2006，Vol.16Issue(19)：2888-2890,2896,4.
广东汉族人群KIR-HLA信号系统多样性研究
Diversity of KIR-HLA signal system in guangdong han population
尹晓林 1邓兰 2马红京 2郭坤元 2张新华 1周天红1
作者信息
- 1. 解放军第303医院,血液科,广西,南宁,530021
- 2. 南方医科大学珠江医院,血液科,广东,广州,510282
- 折叠
摘要
Abstract
[Objective] To investigate the distribution of KIR-HLA signal system in Guangdong Han population.[Methods] 79 cases of healthy donors from Guangdong Han population were studied. SSP and SSOP were used to type HLA-A, B Cw. KIR typing was realized through SSP. Frequency of KIR-HLA combination is analyzed, [Results] KIR2DL2/3-HLA-CwAsn80 (65.8%) was the main inhibitorv KIR-HLA combination, then KIR3DL1-HLA-BBw4(62.6%), KIR3DL1-HLA-A11 (54.2%), and KIR2DL1-HLA-CwLys80 (25.4%). Frequencies of expressing KIR2DL1,KIR2DL2/3 or KIR3DL1 without corresponding HLA ligand were 63.3%(50 cases), 1.3%(1 case), 31.6%(25 cases),respectively. Frequencies of KIR2DS1-HLA-CwLys80, KIR2DS2-HLA-CwAsn80, KIR3DS1-HLA-BBw4 were 2.5% (2cases), 26.6%(21 cases), 16.5%(13 cases), respectively. [Conclusion] KIR-HLA is highly diversity in Guangdong Han population.关键词
杀伤细胞免疫球蛋白样受体/人白细胞抗原/广东汉族/信号系统/多样性Key words
killer cell immunoglobulin-like receptor/human leukocyte antigen/Guangdong Han/signal system/polymorphism分类
医药卫生引用本文复制引用
尹晓林,邓兰,马红京,郭坤元,张新华,周天红..广东汉族人群KIR-HLA信号系统多样性研究[J].中国现代医学杂志,2006,16(19):2888-2890,2896,4.
