中国临床药理学与治疗学2000，Vol.5Issue(4)：289-294,6.
新的抗肿瘤药7-hydroxystaurosporine(UCN-01)抑制肿瘤浸润和转移
Suppression of invasion and migration by 7-hydroxystaurosporine(UCN-01),a new anti-tumor agent
孟庆慧 1邵荣光 1徐静文 1樊赛军1
作者信息
- 1. 长岛Jewish医学中心分子肿瘤实验室,纽约美国
- 折叠
摘要
Abstract
Aim and Methods To investigate the effect of UCN-01(7-hydroxystaurosporine) on cell migration and invasion ability of DU-145, an invasive human prostate cancer cell line.Results It was found that UCN-01 at non-cytotoxic doses (100 nmol· L-1) significantly inhibited prostate cancer DU-145 cell invasion and migration behaviors.Moreover, this anti-invasion and migration activity of UCN-01 was associated with an up-regulation of cell adhesion molecule E-cadherin. Conclusion These results indicate for first time that UCN-01 inhibits the invasion and migration of human prostate cancer cells.Thus, clinical application of UCN-01 may contribute to the potential benefit for suppression of prostate cancer invasion and metastasis.关键词
7-hydroxystaurosporine(UCN-01)/前列腺/肿瘤/浸润/转移Key words
7-hydroxystaurosporine(UCN-01)/prostate/tumor/invasion/migration分类
医药卫生引用本文复制引用
孟庆慧,邵荣光,徐静文,樊赛军..新的抗肿瘤药7-hydroxystaurosporine(UCN-01)抑制肿瘤浸润和转移[J].中国临床药理学与治疗学,2000,5(4):289-294,6.
