首页|期刊导航|南京医科大学学报（英文版）|Effect of behavior training on learning, memory and the expression of NR2B, GluR1 in hippocampus of rats offspring with fetal growth restriction
南京医科大学学报（英文版）2008，Vol.22Issue(5)：290-294,5.
Effect of behavior training on learning, memory and the expression of NR2B, GluR1 in hippocampus of rats offspring with fetal growth restriction
Effect of behavior training on learning, memory and the expression of NR2B, GluR1 in hippocampus of rats offspring with fetal growth restriction
摘要
Abstract
Objective: To study effects of behavior training on learning, memory and the expression of NR2B, GIuR1 in hippocampus of rat's offspring with fetal growth restricfion(FGR). Methods: The rat model of FGR was established by passive smoking method. The rats offspring were divided into the FGR group and the control group, then randomly divided into the trained and untrained group, respectively. Morris water maze test was procezded on postnatal month(PM2/4) as a behavior training method, then the learning-memory of rats was detected through dark-avoidance and step-down tests. The expressions of NR2B and GluR1 suhunits in hippocampal CA1 and CA3 areas were detected by immunohistochemical method. Results: In the dark-avoidance and step-down tests, the performance record of rats with FGR was worse than that of control rats, and the behavior-trained rats was better than the untrained rats, when the FGR model and training factors were analyzed singly. The model factor and training factor had significant interacfion(P ＜ 0.05). The expressions of NR2B and GIuR1 subunits in hippocampal CA1 and CA3 areas of rats with FGR reduced. In contrast, the expressions of GIuR1 and NR2B subunits in CA1 area of behavior-trained rats increased, when the FGR model and training factors were analyzed singly. Conclusion: These findings suggested that the effect of behavior training on the expressions of NR2B and GiuR1 subunits in CA1 area should be the mechanistic basis for the training-induced improvement in learning-memory abilities.关键词
FGR/learning and memory/behavior training/NR2B/GluR1Key words
FGR/learning and memory/behavior training/NR2B/GluR1分类
医药卫生引用本文复制引用
Chunfang Li,Wenli Gou,Yunping Sun,Huang Pu..Effect of behavior training on learning, memory and the expression of NR2B, GluR1 in hippocampus of rats offspring with fetal growth restriction[J].南京医科大学学报（英文版）,2008,22(5):290-294,5.基金项目
This study was supported by the National Natural Science Foundationof China(30471826) （30471826）
