中国临床药理学杂志2009，Vol.25Issue(4)：291-293,297,4.
盐酸左旋沙丁胺醇治疗轻、中度支气管哮喘的随机双盲对照多中心临床研究
Randomized double-blind control multicenter clinical study of levalbuterol hydrochloride in the treament of mild-moderate asthma
马锦芳 1赵子文 2袁本通 3陈平雁 4郑劲平1
作者信息
- 1. 广州医学院第一附属医院,广州呼吸疾病研究所呼吸内科,广州,510120
- 2. 广州市第一人民院呼吸科,广州,510180
- 3. 深圳市第二人民医院呼吸科,广东,深圳,100730
- 4. 南方医科大学统计教研室,广州,510515
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of levalbuterol hydrochloride in the treatment of mild - moderate asthma. Methods Randomized double -blind, control clinical study was carried out. One hundred twenty- two mild- moderate asthma patients were randomized to enroll the study. Trial group was treated with oral Ievalbuterol hydrochlo-ride tablets 1.15 nag thrice daily. Control group was treated with oral sal-butamol sulphate tablets 2 mg thrice daily. The therapy window is ( 14 ±2) d. Results Comparison with baseline, the first forced expiratory vol-ume vs predicted( FEV1% ), the first forced expiratory volume (FEV1)and the first forced expiratory volume vs the forced vital capacity (FEV1/FVC) were obviously improved in trial group. There is significantly statis-ties difference (P≤0. 05 ). Control group has no significant variance pre and post treatment. Drug adverse reaction of trial group and control group is 12.5% and 15.3% ,respectively. There is no marked difference between two groups. Conclusion Two groups are equivalent in the treatment of mild to moderate asthma, moreover, lung function has been more improved greatly in trial group compared with control group.关键词
盐酸左旋沙丁胺醇/硫酸沙丁胺醇/支气管哮喘Key words
levalbuterol hydrochloride/salbutamol sulphate/asthma分类
医药卫生引用本文复制引用
马锦芳,赵子文,袁本通,陈平雁,郑劲平..盐酸左旋沙丁胺醇治疗轻、中度支气管哮喘的随机双盲对照多中心临床研究[J].中国临床药理学杂志,2009,25(4):291-293,297,4.
