中国临床康复2003，Vol.7Issue(21)：2914-2915,2.
脂糖舒对2型糖尿病大鼠胰岛素抵抗的影响
Effects of Zhitangshu on insulin resistance in rats with type 2 diabetes mellitus
摘要
Abstract
AIM:To observe the improving the effects of Zhitangshu(ZTS) in improving insulin resistance in rats with type 2 diabetes mellitus . METHODS:The diabetic rats models were established by streptozotocin(STZ) injection,which were treated respectively with ZTS,metformin hydrochloride tablets(MHT)and gliclazid tablets(GCT) for 9 weeks .The glucose tolerance and the contents of insulin,glucose,triacylglycerol(TG),non-esterified fatty acid(NEFA), total cholesterol(TC),low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol(HDL-c) of the rats were detected,the total body and fatty tissues of rats were weighed respectively, and the insulin resistance index(IRI) was measured . RESULTS:The effects of ZTS to inhibit the increase of total body and fatty tissue and to lower NEFA, LDL-c and IRI were better than GCT (P< 0.01 orP< 0.001),showing also better effect to reduce NEFA and TC than MHT(P< 0.05), but its effects on the rest indexes including IRI-lowering IRI effect were similar to MHT(P > 0.05).ZTS showed a dose-dependent effect in lowering IRI. CONCLUSION:ZTS has obvious effect to improve insulin resistance in rats with type 2 diabetes mellitus.关键词
脂糖舒/2型糖尿病/胰岛素抵抗/大鼠分类
医药卫生引用本文复制引用
舒思洁,舒慧,甘佑仙,吴基良..脂糖舒对2型糖尿病大鼠胰岛素抵抗的影响[J].中国临床康复,2003,7(21):2914-2915,2.基金项目
湖北省教育基金( 2001A4005) （ 2001A4005）
