肝胆胰外科杂志2009，Vol.21Issue(4)：292-295,4.
川芎嗪在大鼠肝脏缺血-再灌注损伤中的保护作用
Protective mechanism of ligustrazine on rat liver during ischemical reperfusion injury
雒洪志 1何延政 2余元龙 1黄宗海 3陈宏1
作者信息
- 1. 中山市人民医院博士后工作站,广东,中山,528400
- 2. 泸州医学院附属医院血管外科,四川泸州,646000
- 3. 南方医科大学珠江医院胃肠外科,广东,广州,510515
- 折叠
摘要
Abstract
Objective To investigate whether Chinese tra-ditional medicine ligustrazine has protective effects during ischemical reperfusion injury of rat liver. Methods One hundred and thirty two SD rats were randomly allocated into three groups: group A, group B and group C. One week survival rate and the plasm index of ALT, AST and LDH were observed. The morphological changes of rat liver were observed under light microscope and electron microscope. The apoptosis index of hepatocyte was detected with im-munohistochemical staining method. Results One-week sur-vival rate in group A 100% (16/16) was higher than that in group B (20%, 8/20) and C (60%, 12/20) (P<O.05). Plasm index of ALT, AST and LDH in group C and group B was higher than that in group A (P<0.05), Moreover, group C was lower than that in group B (P<0.05). Under light mi-croscopy, the hepatocyte necrosis in the group C was very slight. Changes of organelles in group B were obvious under electron microscopy. The apoptosis index of B and C groups was higher than that in group A (P<0.05). Moreover, the index of group B was higher than that of group C (P<0.05). Conclusion Ligustrazine has obvious protective effect during ischemical reperfuson injury of rat liver.关键词
川芎嗪/大鼠/缺血-再灌注/肝/凋亡Key words
ligustrazine/rats/ischemical reperfusion(I/R)/liver/apoptosis分类
医药卫生引用本文复制引用
雒洪志,何延政,余元龙,黄宗海,陈宏..川芎嗪在大鼠肝脏缺血-再灌注损伤中的保护作用[J].肝胆胰外科杂志,2009,21(4):292-295,4.
