中山医科大学学报2001，Vol.22Issue(1)：29-32,4.
雌激素孕激素及促性腺激素对卵巢癌细胞株H0-8910体外生长的调控
Study of the Regulatory Effects of Estrogen Progesterone and Gona dotropins on Growth of Ovarian Cancer Cell Line H0-8910 in Vitro
陈红 1胡琢英 2邓晓谷2
作者信息
- 1. 深圳宝安区人民医院妇产科,
- 2. 重庆医科大学 附属第一医院妇产科,
- 折叠
摘要
Abstract
【Objective】 The study was carried out to investigate t he effects of estradiol(E2), follicle-stimulating hormone(FSH) and progestero ne(P) on the proliferation of ovarian cancer cell line H0-8910 in vitro. 【 Method】 Cultivating human ovarian serous cystadenocarcinoma cell line H0-8910 in vitro, comparing cell numbers using MTT method, flow cytometry detecting cell cycle. 【Results】 After incubation with 10-12 mol/L E2 or 10 μg/L FSH for 48 hours, cell proliferation increased significantly. E2 and FSH increased th e cells percentage in Sphase and G2/M phase of cell cycle respectively P could inhibit H0-8910 cells growth significantly in a dose-dependent manner. 【Conc lusion】 It is suggested that E2 and FSH can stimulate the proliferation of ov arian cancer cell, P can inhibit cell growth.关键词
卵巢肿瘤/药物疗法/雌激素/药理学/孕激素/药理学/促性 腺激素/药理学/激素/治疗应用分类
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陈红,胡琢英,邓晓谷..雌激素孕激素及促性腺激素对卵巢癌细胞株H0-8910体外生长的调控[J].中山医科大学学报,2001,22(1):29-32,4.
