中国现代医学杂志2004，Vol.14Issue(24)：29-32,36,5.
粘着斑激酶(FAK)在大肠上皮不同病变中的表达及意义
Expression of focal adhesion kinase protein in different colonic lesions and its clinical significance
李楠 1顾凯华 1朱建华 1范志忠2
作者信息
- 1. 解放军总医院309临床部,消化科,北京,100091
- 2. 解放军总医院309临床部,病理科,北京,100091
- 折叠
摘要
Abstract
Objective: To detect the role of the FAK expression in different human colonic lesions and normal tissues. Further, to get the correlation between expression of FAK and clinicopathological data including tumor differentiation, Duke's stage etc. Methods: Using SP immunohistochemical techniques combined with imaging,the expression of FAK was analysed in 49 colonic Carcinoma, 23 adenoma and 10 polypoid lesions. Results: FAK was weakly expression in most benign colonic epithelium but was up-regulated at moderate or strong levels in invasive colon carcinoma. Immunohistochemical analyses revealed a correlation between tumor stage and the levels of FAK,especially positively expressed on vascular endothelium and lymphatic endothelium of adjacent infiltration carcinoma. The staining of FAK was higher in cancer of low differentiation cell than of well differentiation. The cancer with metastasis had more FAK protein than the cancers without metastasis. FAK expression levels were significantly related to Duke' s stage. FAK expression levels were not related to tumor size. Conclusion: FAK is significantly overexpressed in colon carcinoma, implying that FAK may play an important role in colon carcinomas or colon carcinoma progression. FAK protein expression level in colon cancer tissues may serve as a new parameter for judging tumor biological behavior and judging prognosis.关键词
大肠肿瘤/肿瘤转移/免疫组织化学/粘着斑激酶Key words
colon/malignant tumor/, focal adhesion kinase (FAK)/immunohistochemistry/imaging analysis分类
医药卫生引用本文复制引用
李楠,顾凯华,朱建华,范志忠..粘着斑激酶(FAK)在大肠上皮不同病变中的表达及意义[J].中国现代医学杂志,2004,14(24):29-32,36,5.
