中德临床肿瘤学杂志（英文版）2007，Vol.6Issue(3)：293-295,3.
奥施康定治疗中重度癌痛疗效观察
Clinical efficacy of OxyContin in the treatment of cancer pain
Xiaomei Li 1Duanqi Liu1
作者信息
- 1. Department of Oncology,General Hospital of Beijing Military Command,Beijing 100700,China
- 折叠
摘要
Abstract
Objective:To evaluate the analgesic efficacy as well as adverse effects of OxyContin for the treatment of moderate to severe cancer pain.Methods:OxyContin was administered at an initial dose of 10 ma every 12 h and titrated upwards according to the extent of pain relief.The analgesic effect,Karnofsky performance status(KPS)scale as well as adverse effects were investigated.Results:The mean onset time and duration of analgesic effect was 41 min and 12.6 h.respectively.with the daily average dose of 69.03mg.Among all the 31 patients who had suffered moderate to severe pain.slight pain relief was achieved in one patient(3.23%).Moderate,obvious and complete pain relief were achieved in 4(12.90%),20 (64.52%)and 6 (19.53%),respectively.KPS was elevated in 19 (61.29%) and stable in 9 (29.03%)patients after administration of OxyContin.3(9.68%)patients were died of disease deterioration.Main adverse effect was constipation in 10 cases(32.26%).Conclusio:OxyContin was effective in the treatment of moderate to severe cancer pain.with rapid onset,good analgesic performance,mild adverse effect and safety profile.关键词
OxyContin/cancer painKey words
OxyContin/cancer pain分类
医药卫生引用本文复制引用
Xiaomei Li,Duanqi Liu..奥施康定治疗中重度癌痛疗效观察[J].中德临床肿瘤学杂志（英文版）,2007,6(3):293-295,3.
