生殖医学杂志2001，Vol.10Issue(1)：29-33,5.
米非司酮对早孕蜕膜组织中IV型胶原
及纤维粘连蛋白的影响
The effects of mifepristone on collagen type IV and fibronectin in human decidua
摘要
Abstract
Objective: To study the effects of mifepristone on collagen type IV and fibronectin in human decidua during first trimester of pregnancy for further investigating the mechanisms of antigestational action of mifepristone.
Methods: Fifty-five women with early pregnancy (≤60 gestational days) were divided into treatment group (mifepristone 150 mg administered) and control group randomly. Immunohistochemical technique (ABC method) was carried out to examine the distribution of collagen type IV and fibronectin in decidua of both groups.
Results: Compared with control group, the levels of decidual collagen type IV and fibronectin in treatment group were significantly decreased (P<0.01,P<0.05).Particularly, the contents of collagen type IV in glandular basal membrane and the fibronectin in extracellular matrix (ECM) were significantly reduced (P<0.01).
Conclusion: The results suggested that the anti-gestational effect of mifepristonemay act through decreasing the decidual collagen type IV and fibronectin. The concen-trations of these two componentes in ECM of decidua might be related by progesterone and corticosteroid.关键词
米非司酮/IV型胶原/纤维粘连蛋白/蜕膜
米非司酮/IV型胶原/纤维粘连蛋白/蜕膜分类
医药卫生引用本文复制引用
王玉贤,李翘竹..米非司酮对早孕蜕膜组织中IV型胶原
及纤维粘连蛋白的影响[J].生殖医学杂志,2001,10(1):29-33,5.
