中国现代医学杂志2004，Vol.14Issue(17)：29-33,36,6.
针刺肝经腧穴对偏头痛大鼠脑干组织G蛋白含量的影响
Effect of acupuncture liver channel of points on content of G protein alpha subunits in the rat brain stem after nitroglycerin infusion
钟广伟 1李炜 1王素娥 1李臻琰 1文玲波1
作者信息
- 1. 中南大学湘雅医院,新医科,湖南,长沙,410008
- 折叠
摘要
Abstract
Objective: In order to explore the effect of acupuncture the liver channel of points on the content of G protein alpha subunits in the rat brain stem after nitroglycerin infusion. Methods: The model of migraine rats were reproduced in accordance with Knynihar-tassorelli methods by infusing the NO lonor nitroglycerin [glyceryl trintrate (GTN)] i.h, then the rats were divided randomly into four groups: Normal control group, Saline control group, Model control group and Acupuncture treatment group. The content of Giα and Gsα protein in the rat brain stem was analysed by western blot method. Results: The model control group of the content of Gsα protein in the rat brain stem was significantly raised (P ＜0.01), the Giα protein was significantly reduced (P ＜0.01), and the ration of Gsα/Giα was increased by comparison with the normal control group. The acupuncture group of Gsα protein in the rat brain stem went up apparently than the model group (P ＜0.01), and Giα protein was slightly higher than the model group (P ＜0.01), resulting in reducing of Gsα/Giα rations. Conclusion: Our results provided important information for understanding how G-protein-linked signaling system play an important role in the attacking migraine, and the mechanisms of acupuncture on migraine was possibility that the acupuncture mediated the G-protein-linked signal transduction pathway plays an important function.关键词
偏头痛/针刺疗法/G蛋白/大鼠/免疫印迹法Key words
migraine/acupuncture/G protein/rat/western blot analysis分类
医药卫生引用本文复制引用
钟广伟,李炜,王素娥,李臻琰,文玲波..针刺肝经腧穴对偏头痛大鼠脑干组织G蛋白含量的影响[J].中国现代医学杂志,2004,14(17):29-33,36,6.
