广东医学2001，Vol.22Issue(4)：293-395,103.
肝细胞癌组织中HBV，HCV，HGV的表达
Hepatitis viruses in hepatocellular carcinoma
摘要
Abstract
Objective To investigate the pattern of hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis G virus (HGV) in tissues of hepatocellular carcinoma (HCC) and para-HCC. Methods HBV S antigen (HBsAg), HCV NS5 antigen (HCAg) and HGV NS5 antigen (HGAg) were detected respectively in paraffin-embedded HCC tissues from 26 cases of patients with HCC by using immunohistochemical method (SPAB) with three monoclonal antibodies of anti-HBs, anti-HCV NS5 and anti-HGV NS5. Results The positive rate of HBsAg, HCAg and HGAg was 65%(17/26), 50%(13/26) and 35%(9/26), respectively. There were overlapping infection of HBV/HCV/HGV in 7 cases and HBV/HCV in 4 cases. 6 cases of HBV, 2 cases of HCV and 2 cases of HGV were all single infection. 5 cases were negative for three antigens. there were significant difference between HBV and HGV infection and no significant difference between HBV and HCV, HCV and HGV infection. All three antigens expressed in cytoplasma of liver or HCC cells, in thin granular pattern. Expression of the three antigens in HCC cells was weaker than that in para-HCC cells. Conclusion There are high infection rates of HBV, HCV and HGV in patients with HCC, in the order of HBV, HCV and HGV. HBV infection may play an important role, in the development of HCC while HCV and HGV infecction are related factors.关键词
乙型肝炎病毒/丙型肝炎病毒/庚型肝炎病毒/肝细胞癌/免疫组织化学法分类
医药卫生引用本文复制引用
唐漾波,谭奕洲,张惠忠,唐小平,侯景辉..肝细胞癌组织中HBV，HCV，HGV的表达[J].广东医学,2001,22(4):293-395,103.基金项目
本课题受广东省医学科学技术研究基金资助(编号： A1998529) （编号： A1998529）
