中国临床药理学与治疗学2005，Vol.10Issue(1)：29-39,11.
口服及静注乙醇后血中乙醇与β-羟丁酸,乙酰乙酸,乳酸及丙酮酸浓度关系的探讨:一项群体药效动力学的研究
Relationship between plasma concentration of β-hydroxybutyrate,acetoacetate, lactate and pyruvate and alcohol after oral or intravenous administration of alcohol to normal human subjects: a population pharmacodynamics (PD) analysis
摘要
Abstract
To investigate the relationship between plasma concentration of β-hydroxybutyrate, acetoacetate, lactate, pyruvate, β-hydroxybutyrate/acetoacetate (H/A ratio) and lactate/pyruvate (L/P ratio) and alcohol by population PD analysis after oral or intravenous administration of alcohol. METHODS: An oral dose of alcohol tered to 14 normal human subjects and an Ⅳ infusion (30 water was administered to 8 normal subjects. Venous blood was sampled for determination of alcohol (BAC),β-hydroxybutyrate, acetoacetate, lactate and pyruvate for 380 min after oral administration and for 340 min after Ⅳ administration. RESULTS: After oral administration,The slope β for eliminate-phase was 2.29 ± 0.50 oral or Ⅳ administration, the relationship between BAC and β-hydroxybutyrate, acetoacetate, lactate and pyruvate concentration and H/A and L/P ratio were investigated by population physiologic indirect response model, and the parameters were presented. Meanwhile, the H/A did not reach maximum at the end of the elimination phase of the alcohol, and it suggested that the liver continue to accumulate NADH at zero-orden metabolism phase of alcohol.The plot of BAC versus the plasma concentration of lactate showed an apparent counter-clockwise hysteresis. CONCLUSION: In general, venous blood L/P ratio is not a suitable index for the real time reflection of liver redox status because of the time lag change in concentration of lactate after administration of ethanol. The parameters provided here can be useful for future researches on the effect of alcohol on liver redox status.关键词
药代动力学/药效动力学/群体药效学/乙醇/β-羟丁酸Key words
pharmacokinetics/pharmacodynamics/population PD model/ethanol/β-hydroxybutyrate分类
医药卫生引用本文复制引用
万捷,李建国,HUI C ko,Tom LIONETTI,David T GEORGE,Susan E SHOAF..口服及静注乙醇后血中乙醇与β-羟丁酸,乙酰乙酸,乳酸及丙酮酸浓度关系的探讨:一项群体药效动力学的研究[J].中国临床药理学与治疗学,2005,10(1):29-39,11.基金项目
Project supported by NIH Intramural Research Fund （）
