中国当代儿科杂志2003，Vol.5Issue(4)：294-296,300,4.
儿童急性白血病Bcl-2基因MDR1基因表达及意义
Expression of Bcl-2 and MDR1 Genes in Children with Acute Leukemia
何莉 1胡宛如 1郭承吉1
作者信息
- 1. 中国医科大学附属第一医院儿科,沈阳,辽宁,110001
- 折叠
摘要
Abstract
Objective To investigate the expression and significance of Bcl-2 and MDR1 genes in children with acute leukemia. Methods The expressions of Bcl-2 and MDR1 genes in 36 cases of acute leukemia and 10 cases of idiopathic thrombocytopenic purpura in the control group were examined by RT-PCR. Results The expressions of Bcl-2 in the incipient group and relapsed group were higher than that of the control group (P<0.05). While in the incipient group and complete remission group, they were lower than that of the relapsed group (P<0.01). The expression of MDR1 gene in the relapsed group was higher than those of control group, incipient group and complete remission group (P<0.01 or 0.05). There was no difference of MDR1 expression between the incipient group and the control group or the complete remission group and the control group (P>0.05). There was no close relationship between the levels of Bcl-2 or MDR1 and clinical features such as gender, age, initial WBC count, the percent of carcinocytes, hepatomegaly, splenomegaly and lymphadenhypertrophy (P>0.05). The relationship between Bcl-2 and MDR1 genes was not significant (rs=0.308, P>0.05). Conclusions Bcl-2 and MDR1 genes were associated with drug resistance by different mechanisms.关键词
白血病/Bcl-2基因/MDR1基因/耐药Key words
Leukemia/Bcl-2 gene/MDR1 gene/Drug resistance分类
医药卫生引用本文复制引用
何莉,胡宛如,郭承吉..儿童急性白血病Bcl-2基因MDR1基因表达及意义[J].中国当代儿科杂志,2003,5(4):294-296,300,4.
