中国现代医学杂志2007，Vol.17Issue(24)：2945-2948,4.
同种异体血管移植后TNF在血管和心肌组织中的表达
Expression of tumor necrosis factor in blood vessels and myocardium after allogenic vasotransplantation
陈晓慨 1白菡 2朱兵 1徐世安 1王练英3
作者信息
- 1. 中国医科大学附属盛京医院,心脏外科,辽宁,沈阳,110004
- 2. 中国医科大学附属盛京医院,感染科,辽宁,沈阳,110004
- 3. 中国医科大学附属盛京医院,小儿外科,辽宁,沈阳,110004
- 折叠
摘要
Abstract
[Objective] To study the variance of tumor necrosis factor (TNF) in grafted blood vessels and myoeardium.[Methods] The carotid vasotransplantation was performed with male mature Japanese albino rabbits as vascular recipients and New Zealand rabbits as vascular donors.Immunohistochemical methods were used to detect TNF expression in grafted blood vessels and myoeardium.[Results]TNF positive expression was lower in the autoorthotopie transplantation group and the liquid nitrogen frozen group than that in the fresh transplantation group and the antibiotic-treated group.And as compared with the other groups,the positive expression of TNF was the highest in the fresh transplantation group,and there was statistic significance(P＜0.05).After vasotransplantation,the findings of myocardium were allogenic as vasotransplantation.TNF expression was higher in fresh transplantation group than that in the other groups.Compared with auto-orthotopie transplantation group and liquid nitrogen frozen group,there was statistical significance(P＜0.05).However,compared with antibiotic-treated group,there was no statistic significance.[Conclusions]TNF expression of myocardium and transplanted vessel may be depressed by pre-treat-ment with liquid nitrogen frozen.Ischemia reperfusion injures and/or immunological rejection may stimulate the produetion of TNF in grafted blood vessels and many organs and induce the pathological lesions of grafted vasculature.关键词
血管移植/肿瘤坏死因子/心肌组织Key words
allogenie vasotransplantation/tumor necrosis factor (TNF)/myoeardium分类
医药卫生引用本文复制引用
陈晓慨,白菡,朱兵,徐世安,王练英..同种异体血管移植后TNF在血管和心肌组织中的表达[J].中国现代医学杂志,2007,17(24):2945-2948,4.
