解放军医学杂志2001，Vol.26Issue(4)：295-297,3.
异基因外周血造血干细胞移植治疗慢性髓细胞白血病的临床研究
ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION（PBSCT） FOR CHRONIC MYELOGENOUS LEUKEMIA
宋献民 1王健民 1居小萍 1章卫平 1童书鹏 1陈莉 1侯军 1翟勇平 1闵碧荷 1张洁1
作者信息
摘要
Abstract
To observe the efficacy of allo-PBSCT in chronic myelogenous leukemia(CML)， twelve patients with chronic phase CML were treated with allo-PBSCT. The median age was 32.5 years. Donors received G-CSF 5μg／(kg*d) for 5 days. A median mononuclear cell of 5.0×108/kg recipient weight [range （2.4～9.57）×108/kg], including a median CD34+ cell of 5.82×106/kg [range （0.72～66.30）×106/kg] , was collected. Conditioning regimens for nine patients and three patients were TBI+CTX+VP16 and TBI + CTX respectively. The extra radiation of spleen was given to three patients with splenomegaly. All patients were engrafted and hematopoietic reconstitution was rapid, with neutrophils recovering to over 0.5×109/L on day 14.5（range 14～23）and platelets >20×109/L on day 16 (range 9～35）.Over grade Ⅱ acute GVHD occurred in three patients(25%) and chronic GVHD occurred in five patients, including three patients with localized chronic GVHD and two with extensive chronic GVHD . The incidence of acute GVHD in allo-PBSCT is similar to allo-BMT, while care should be taken for the occurrence of chronic GVHD.关键词
慢性髓细胞白血病/造血干细胞移植分类
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宋献民,王健民,居小萍,章卫平,童书鹏,陈莉,侯军,翟勇平,闵碧荷,张洁..异基因外周血造血干细胞移植治疗慢性髓细胞白血病的临床研究[J].解放军医学杂志,2001,26(4):295-297,3.
