中国肺癌杂志2008，Vol.11Issue(3)：297-305,9.
Oxidative stress in tumor microenvironment——Its role in angiogenesis
Oxidative stress in tumor microenvironment——Its role in angiogenesis
Armando ROJAS 1Raúl SILVA 1Héctor FIGUEROA 1Miguel A MORALES2
作者信息
- 1. School of Medicine, Catholic University of Maule, Chile
- 2. CBM, University of Chile, Chile
- 折叠
摘要
Abstract
The tumor angiogenesis process is believed to be dependent on an "angiogenic switch" formed by a cascade of biologic events as a consequence of the "cross-talk" between tumor cells and several components of local microenvironment including endothelial cells, macrophages, mast cells and stromal components. Oxidative stress represents an important stimulus that widely contributes to this angiogenic switch, which is particularly relevant in lungs,where oxidative stress is originated from different sources including the incomplete reduction of oxygen during respiration,exposure to hypoxia/reoxygenation, stimulated resident or chemoattracted immune ceils to lung tissues, as well as by a variety of chemicals compounds. In the present review we highlight the role of oxidative stress in tumor angiogenesis as a key signal linked to other relevant actors in this complex process.关键词
Oxidative stress Tumor angiogenesis NOX enzymes Nitric oxide VEGF Cadherins Advanced glycationKey words
Oxidative stress Tumor angiogenesis NOX enzymes Nitric oxide VEGF Cadherins Advanced glycation分类
医药卫生引用本文复制引用
Armando ROJAS,Raúl SILVA,Héctor FIGUEROA,Miguel A MORALES..Oxidative stress in tumor microenvironment——Its role in angiogenesis[J].中国肺癌杂志,2008,11(3):297-305,9.
