南京医科大学学报（英文版）2007，Vol.21Issue(5)：298-301,4.
Effects of emodin on the proliferation of the glomerular mesangial cell and correlative cytokines in rats
Effects of emodin on the proliferation of the glomerular mesangial cell and correlative cytokines in rats
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作者信息
- 1. Department of Integrated Chinese Traditional and Western Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shanxi Province, China;Department of Hematology, the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004, Shanxi Province, China;Department of Integrated Chinese Traditional and Western Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shanxi Province, China;Department of Integrated Chinese Traditional and Western Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shanxi Province, China
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摘要
Abstract
Objective:To investigate the effects of emodin(EMD) on cell proliferation and correlative cytokines secretion of glomerular mesangial in rats. Methods:The effects of EMD on cell proliferation and IL-6 , TGF-β1 secretion of glomerular mesangial in rats were observed. Cell proliferation was measured by MTT method. IL-6 and TGF-β1 secretion was detected with ELISA. Results:EMD was able to inhibit the cell proliferation and down-regulate the IL-6 and TGF-β1 secretion of glomerular mesangial, as compared to the model group in rats (P＜0.05). Conclusion:EMD could significantly inhibit the cell proliferation, and reduce the creation of extracellular matrix(ECM), this indicated that it could play an important role in alleviation and prevention of glomerular sclerosis. The mechanism may be that EMD can reduce the IL-6 and TGF-β1 secretion of glomerular mesangial cell in rats.关键词
emodin/ glomerular mesangial cell/ mesangial cell proliferation/ correlative cytokinesKey words
emodin/ glomerular mesangial cell/ mesangial cell proliferation/ correlative cytokines分类
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..Effects of emodin on the proliferation of the glomerular mesangial cell and correlative cytokines in rats[J].南京医科大学学报（英文版）,2007,21(5):298-301,4.
