口腔颌面外科杂志2001，Vol.12Issue(4)：298-302,5.
舌鳞状细胞癌患者血清VEGF水平的定量分析
A QUANTITATIVE ANALYSIS OF SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR LEVELS IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE TONGUE
摘要
Abstract
Objective Angiogenesis is a crucial step in tumor growth, progression, and metastasis. Recently, many angiogenic factors have been identified. Vascular endothelial growth factor (VEGF) is thought to be one such angiogenic factor and is also thought to be a selective mitogen for vascular endothelial cells. The present study was designed to determine the circulating levels of VEGF in human squamous cell carcinoma of the tongue (SCCT) and to investigate its correlation with the clinicopathologic features and prognosis. Methods The study consisted of 10 healthy volunteers and 31 patients with squamous cell carcinoma of the tongue. A quantitative sandwich enzyme immunoassay technique was used to measure the concentrations of VEGF in the sera. The data obtained from the experiment were analyzed with independentsamples t test. Results The mean concentrations of serum VEGF were 148.80 + 64. 17pg. Ml-1 (range, 59 ～ 231 pg. Ml- 1 ) in normal controls and 567.97 + 338.17pg. Ml-1 (range, 136 ～ 1892pg. Ml - 1 ) in SCCT group. Statistical analysis showed that the mean VEGF level in sera of SCCT patients was significantly higher than that in healthy controls( P ＜0 .001 ). The serum VEGF levels of SCCT patients correlated with condition of nodal metastasis (P ＜ 0.05) and clinical stage ( P ＜ 0.05) but not with sex ( P ＞ 0.05) and degree of differentiation ( P ＞ 0.05). Conclusion Our study showed that SCCT was associated with significantly elevated serum VEGF concentration. Higher level of serum VEGF also correlated with lymph node metastasis and clinical stage of SCCT.关键词
舌鳞状细胞癌/血管内皮生长因子/免疫学引用本文复制引用
尚政军,李金龙,李祖兵..舌鳞状细胞癌患者血清VEGF水平的定量分析[J].口腔颌面外科杂志,2001,12(4):298-302,5.
