中国临床康复2004，Vol.8Issue(15)：2996-2997,2.
游泳对慢性低氧高二氧化碳大鼠一氧化氮代谢的影响
Effects of swimming exercise on nitric oxide content and nitric oxide synthase activity in rats exposed chronically to hypoxia and hypercapnia
摘要
Abstract
BACKGROUND: Sports could increase the nitric oxide (NO) production of vessels for normal organism and patients with cardiac diseases [2], while sports have an active role in metabolism of NO when chronic hypoxia.OBJECTIVE: To study the effects of swimming exercise on NO metabolism and mean pulmonary artery pressure(mPAP) in rats exposed chronically to hypoxia-hypercapnia.SETTING, PARTICIPANTS and INTERVENTIONS: The study was made in the Institute of Cot Pulmonale, Wenzhou Medical College. Thirty-one Sprague-Dawley(SD) rats were randomly divided into two groups: normal control group( n = 10) and chronic hypoxia-hypercapnia group( n = 21) .After four weeks of exposure to hypoxia-hypercapnia, the latter group was suhdivided into hypoxia-hypercapnia(HH) control group( n = 8) and swimming exercise (SE) group ( n = 13 ). Contents of nitrate/nitrite in plasma, and pulmonary and right ventricular homogenates were measured with colorimetric analysis. L-citrulline was determined with liquid scintillometer, and the activity of NO synthase(induced NOS, total NOS, constitutive NOS) in pulmonary and right ventricular homogenates was counted.RESULTS: The NO2/NO3 contents and cNOS activity in plasma, and pulmonary and right ventricular homogenate in the SE group were markedly higher than those in the HH group. Moreover, mPAP in the SE group [(19.62±1.32) mm Hg] was obviously lower than that in the HH group [(15.19+1.11) mm Hg](q=12.632, P ＜0.01).CONCLUSION: Swimming exercise could increase NO production and lower the mPAP of the rats exposed chronically to hypoxia-hypercapnia.关键词
低氧/病理生理学/二氧化碳/随机分配/一氧化氮/代谢/游泳分类
医药卫生引用本文复制引用
龚永生,黄虹,郑绿珍,胡良冈,梅惠华,李继武,范小芳..游泳对慢性低氧高二氧化碳大鼠一氧化氮代谢的影响[J].中国临床康复,2004,8(15):2996-2997,2.基金项目
浙江省卫生厅(SY960005)和温州市科委(S2001A24)资助项目 （SY960005）
