第一军医大学学报2001，Vol.21Issue(4)：301-302,2.
冠心病患者血清脂氢过氧化物和NO含量的变化
Changes of lipoperoxide and nitric oxide levels in the sera of patients with coronary heart diseases
黄敏珍 1周玫 2陈瑗 2张健3
作者信息
- 1. 第一军医大学南方医院妇产科
- 2. 第一军医大学生物化学教研室
- 3. 第一军医大学卫生处,
- 折叠
摘要
Abstract
Objective To investigate the relationship between the changes in serum lipoperoxide (LOOH) and nitric oxide (NO) levels and the pathogenesis of coronary heart diseases (CHD). Methods The concentrations of LOOH in the sera of 33 healthy subjects and 33 patients with CHD were determined by ferrous oxidation in xylenol orange (FOX) assay, while those of NO by enzymatic one-step assay with nitrate reductase. Results The average serum concentration of LOOH in the patients was (7.64±3.26) μmol/L, much higher than that of healthy subjects [(5.78±3.21) μmol/L, P<0.05]. The NO level was (42.5±18.9) μmol/L in the patients and (51.4±17.8) μmol/L in the healthy subjects, showing significant difference between the 2 groups (P<0.05). Conclusion The increased LOOH and decreased NO levels in the serum might be involved in the pathogenesis of arteriosclerotic heart diseases.关键词
冠心病/血清/脂氢过氧化物/一氧化氮分类
医药卫生引用本文复制引用
黄敏珍,周玫,陈瑗,张健..冠心病患者血清脂氢过氧化物和NO含量的变化[J].第一军医大学学报,2001,21(4):301-302,2.
