中国肿瘤生物治疗杂志2008，Vol.15Issue(4)：301-304,4.
Developing aptamers into tumor diagnostics and therapeutics
Developing aptamers into tumor diagnostics and therapeutics
Jing Mi 1Bryan M. Clary 1Bruce A. Sullenger1
作者信息
- 1. Departments of Surgery, Duke University Medical Center, Durham, NC 27710, USA
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摘要
Abstract
Aptamers are small single-stranded nucleic acid molecules that bind a target protein with high affinity and specificity. Due to their stability, low toxicity and immunogenicity, as well as improved safety, aptamers are attractive alternatives to antibody and are therefore suitable for in vivo applications. Aptamers are typically isolated, through a process termed SELEX (systematic evolution of ligands by exponential enrichment), from combinatorial libraries with desired proteins. In the present review, the recent non-conventional aptamer selection process will be discussed together with an overview on the aptamer application in cancer diagnosis and therapy.关键词
aptamer/systematic evolution of ligands by exponential enrichment (SELEX)/neoplasms diagnosis/neoplasms therapyKey words
aptamer/systematic evolution of ligands by exponential enrichment (SELEX)/neoplasms diagnosis/neoplasms therapy分类
医药卫生引用本文复制引用
Jing Mi,Bryan M. Clary,Bruce A. Sullenger..Developing aptamers into tumor diagnostics and therapeutics[J].中国肿瘤生物治疗杂志,2008,15(4):301-304,4.
