北京中医药大学学报2000，Vol.23Issue(5)：30-32,3.
大鼠拟血管性痴呆模型的建立及中药9602防治作用初探
Establishing of the Imitative Vascular Dementia Rat Model and the Preliminary Study on the Preventive and Treating Effects of TCM Preparation 9602 on the Disease
摘要
Abstract
The imitative vascular dementia rat model was established by repeatedly clipping the common carotid artery of the rat in combination with reducing the rat' s blood pressure to about 50 mm Hg with an abdominal injection of sodium nitroprusside. On the 7th day after cerebral ischemic repeffusion, rats in the model group showed obvious disturbance in study and memory; and their hippocampal CA1 region manifested obvious cell deletion while there was no significant change in the CA3 region. The authors consider this kind of model reliable and reproducible, and suitable for studying the mechanism of the injury caused by cerebral ischemic reperfusion, and for observing the relevant drug effects. In the same experiment, it was found that TCM preparation 9602 could significantly relieve the injury of the hippocamp and the disturbance in study and memory caused by cerebral ischemia.关键词
脑缺血模型/学习记忆/中药9602Key words
Cerebral Ischemic Model/Study and Memory/TCM Preparation 9602分类
医药卫生引用本文复制引用
王蕊,杨秦飞,唐一鹏,房良敏,胡京红,贾绪东,洪庆涛..大鼠拟血管性痴呆模型的建立及中药9602防治作用初探[J].北京中医药大学学报,2000,23(5):30-32,3.基金项目
"九五"国家科技攻关课题(No．906-09-03) （No．906-09-03）
