中德临床肿瘤学杂志(英文版)2003，Vol.2Issue(1)：30-33,4.
尿透明质酸含量诊断膀胱癌的临床研究
The Value of the Measurement of Urinary Hyaluronic Acid Levels for the Diagnosis of Bladder Cancer
杨为民 1蔡建良 1陈志强 1周健1
作者信息
- 1. 武汉华中科技大学同济医学院附属同济医院,430030
- 折叠
摘要
Abstract
Objective To investigate the value of the measurement of urinary hyaluronic acid (HA) levels for the diagnosis of bladder cancerand the possibility of replacing ELISA-like assay with radioimmunoassay to detect the levels of urinary HA.Methods Using the ELISA-like assay and radioimmunoassay at the same time to measure the HA levels in the urine specimensfrom 49 bladder cancer patients, 12 benign bladder tumor patients, 30 other genitourinary disease patients and 20 normal controls.Results There is not much difference between the consequences of the urinary HA levels whether we used the ELISA-like assay orradioimmunoassay to detect every specimen (P ＞ 0.05). When we used the results with radioimmunoassay for analysis ,we foundthe levels of urinary HA of bladder cancer patients were 2 - 4 times than those of the benign bladder tumor patients, other genitou-rinary disease patients or normal individuals ( P ＜ 0.01 ); With 137.5 ngHA/mg protein ( 113.6 + 23.9 ng/mg) as a minimumcutoff limit, this assay had a good sensitivity (91.8%) and specificity (91.9%) for the diagnosis of bladder cancer. Its differencein sensitivity meant a lot when compared with urine cytology (48.9% , P ＜ 0.01 ).Conclusion The urinary HA assay is a simple, convenient, noninvasive, credible and cheap method with satisfactory sensitivityand specificity for the diagnosis of bladder carcinoma; radioimmunoassay is also a good means to measure the urinary HA levels.关键词
膀胱肿瘤/透明质酸/尿Key words
Bladder carcinoma/Hyaluronic acid/Urine分类
医药卫生引用本文复制引用
杨为民,蔡建良,陈志强,周健..尿透明质酸含量诊断膀胱癌的临床研究[J].中德临床肿瘤学杂志(英文版),2003,2(1):30-33,4.
